Voss, M., Chambon, V., Wenke, D., Kühn, S., & Haggard, P. (2017). In and out of control: brain mechanisms linking fluency of action selection to self-agency in patients with schizophrenia. Brain, 140(8), 2226–2239. https://doi.org/10.1093/brain/awx136
Sense of agency refers to the feeling of control over one’s actions, and their consequences. It involves both predictive processes linked to action control, and retrospective ‘sense-making’ causal inferences. Schizophrenia has been associated with impaired predictive processing, but the underlying mechanisms that impair patients’ sense of agency remain unclear. We introduce a new ‘prospective’ aspect of agency and show that subliminally priming an action not only influences response times, but also influences reported sense of agency over subsequent action outcomes. This effect of priming was associated with altered connectivity between frontal areas and the angular gyrus. The effects on response times and on frontal action selection mechanisms were similar in patients with schizophrenia and in healthy volunteers. However, patients showed no effects of priming on sense of agency, no priming-related activation of angular gyrus, and no priming-related changes in fronto-parietal connectivity. We suggest angular gyrus activation reflects the experiences of agency, or non-agency, in part by processing action selection signals generated in the frontal lobes. The altered action awareness that characterizes schizophrenia may be due to impaired communication between these areas.
Sidarus, N., Vuorre, M., & Haggard, P. (2017). Integrating prospective and retrospective cues to the sense of agency: a multi-study investigation. Neuroscience of Consciousness, 2017(1), 1–10. https://doi.org/10.1093/nc/nix012
Sense of agency (SoA) refers to the experience of voluntary control over one’s own actions, and, through them, over events in the outside world. Recent accounts suggest that SoA involves an integration of various cues. These include prospective cues, for example, related to the fluency of action selection, and retrospective cues, linked to outcome monitoring. It remains unclear whether these cues may have independent effects on SoA, and, in particular, how their relative contributions may change during instrumental learning. In the present study, we explored these issues by conducting a multi-study analysis of seven published and unpublished studies on the role of prospective cues to the SoA. Our main question was how the effects of selection fluency on SoA might change as information about action–outcome contingencies is gathered. Results show that selection fluency can have a general and consistent influence on the SoA, independent of outcome monitoring. This suggests selection fluency is used as a heuristic cue, to prospectively inform our SoA. In addition, our results show that the influence of selection fluency on SoA may change systematically as action–outcome contingencies are gradually learned. We speculate that dysfluent selection may impair formation of mental associations between action and outcome.
Sidarus, N., Vuorre, M., & Haggard, P. (2017). How action selection influences the sense of agency: An ERP study. NeuroImage, 150, 1–13. https://doi.org/10.1016/j.neuroimage.2017.02.015
Sense of agency (SoA) refers to the feeling that we are in control of our actions and, through them, of events in the outside world. One influential view claims that the SoA depends on retrospectively matching the expected and actual outcomes of action. However, recent studies have revealed an additional, prospective component to SoA, driven by action selection processes. We used event-related potentials (ERPs) to clarify the neural mechanisms underlying prospective agency. Subliminal priming was used to manipulate the fluency of selecting a left or right hand action in response to a supraliminal target. These actions were followed by one of several coloured circles, after a variable delay. Participants then rated their degree of control over this visual outcome. Incompatible priming impaired action selection, and reduced sense of agency over action outcomes, relative to compatible priming. More negative ERPs immediately after the action, linked to post-decisional action monitoring, were associated with reduced agency ratings over action outcomes. Additionally, feedback-related negativity evoked by the outcome was also associated with reduced agency ratings. These ERP components may reflect brain processes underlying prospective and retrospective components of sense of agency respectively.
Sidarus, N., Vuorre, M., Metcalfe, J., & Haggard, P. (2017). Investigating the prospective sense of agency: Effects of processing fluency, stimulus ambiguity, and response conflict. Frontiers in Psychology, 8, 545. https://doi.org/10.3389/fpsyg.2017.00545
How do we know how much control we have over our environment? The sense of agency refers to the feeling that we are in control of our actions, and that, through them, we can control our external environment. Thus, agency clearly involves matching intentions, actions and outcomes. The present studies investigated the possibility that processes of action selection, i.e. choosing what action to make, contribute to the sense of agency. Since selection of action necessarily precedes execution of action, such effects must be prospective. In contrast, most literature on sense of agency has focussed on the retrospective computation whether an outcome fits the action performed or intended. This hypothesis was tested in an ecologically rich, dynamic task based on a computer game. Across three experiments, we manipulated three different aspects of action selection processing: visual processing fluency, categorisation ambiguity, and response conflict. Additionally, we measured the relative contributions of prospective, action selection-based cues, and retrospective, outcome-based cues to the sense of agency. Manipulations of action selection were orthogonally combined with discrepancy of visual feedback of action. Fluency of action selection had a small but reliable effect on the sense of agency. Additionally, as expected, sense of agency was strongly reduced when visual feedback was discrepant with the action performed. The effects of discrepant feedback were larger than the effects of action selection fluency, and sometimes suppressed them. The sense of agency is highly sensitive to disruptions of action-outcome relations. However, when motor control is successful, and action-outcome relations are as predicted, fluency or dysfluency of action selection provides an important prospective cue to the sense of agency.
Scheveneels, S., Boddez, Y., & Hermans, D. (accepted for publication). Learning mechanisms in fear and anxiety: It is still not what you think it is. In B. Olatunji (Ed.). The Cambridge Handbook of Anxiety and Related Disorders.
Scheveneels S., Boddez Y., Bennett M., Hermans D. (2017). One for all: The effect of extinction stimulus typicality on return of fear. Journal of Behavior Therapy and Experimental Psychiatry, 57, 37-44.
Lijima Y., Takano K., Boddez Y., Raes F., Tanno Y. (2017). Negative Self-Referent Thinking is Less Sensitive to Aversive Outcomes in People with Higher Levels of Depressive Symptoms. Frontiers in Psychology, 8, art.nr. 1333.
Scheveneels S., Boddez Y., Vervliet B., Hermans D. (2016). The validity of laboratory-based treatment research: Bridging the gap between fear extinction and exposure treatment. Behaviour Research and Therapy, 86, 87-94.
Takano K., Boddez Y., Raes F. (2016). I sleep with my Mind’s eye open: Cognitive arousal and overgeneralization underpin the misperception of sleep. Journal of Behavior Therapy and Experimental Psychiatry, 52, 157-165.